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安全药理学主要研究药物及其代谢产物对心血管系统、呼吸系统和中枢神经系统等的影响。通过安全药理学研究,确定药物可能关系到人安全性的非期望药理作用;评价药物在毒理学和/或临床研究中所观察到的药物不良反应和/或病理生理作用;研究所观察到的和可疑的药物不良反应机制。近年来安全药理学研究发展迅速,生物信号遥测系统可用来检测清醒状态下、自由活动动物的多种生理指标;对药物引起的QT间期延长应进行综合风险评估已是共识;计算机毒性预测、人心肌干细胞研究、下丘脑病理组织切片研究、用斑马鱼进行高通量筛选、安全药理学生物标志物探索为准确预测药物的临床毒性奠定了基础。
Safety pharmacology focuses on the effects of drugs and their metabolites on the cardiovascular, respiratory and central nervous systems. The safety pharmacology study identifies the unintended pharmacological effects that the drug may have on human safety; evaluates the adverse drug reactions and / or pathophysiological effects observed by the drug in toxicology and / or clinical studies; and studies observed And suspected adverse drug reaction mechanism. In recent years, the rapid development of safety pharmacology, bio-signal telemetry system can be used to detect sober state, a variety of physiological indicators of free-moving animals; drug-induced QT interval should be carried out comprehensive risk assessment is the consensus; computer toxicity prediction, Human cardiac stem cell research, hypothalamic pathological tissue sections, high-throughput screening with zebrafish, safety pharmacological biomarker exploration to accurately predict the clinical toxicity of the drug laid the foundation.