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叶绿素降解产物是合成光动力治疗药物的理想合成前体.为了获得新型叶绿素类光敏剂,以焦脱镁叶绿酸-d甲酯为起始原料,通过空气氧化反应、Knoevenagel反应、Hener反应、Tiffeneau-Demjanov重排、Friedlaender缩合和还原等经典化学反应对其甲酰基和外接环羰基实施化学修饰,在C(3)-位和外接E-上建立了不同的化学结构,合成出一系列具有叶绿素基本碳架结构的二氢卟吩衍生物,讨论了分子结构与其紫外-可见光谱之间的联系,并对相应的化学反应提出了可能的反应机理.新报道的叶绿素衍生物的化学结构均经UV,IR,1H NMR及元素分析得以证实.
Chlorophyll degradation products are ideal synthetic precursors for the synthesis of photodynamic therapy drugs.In order to obtain a new type of chlorophyll photosensitizer, pyropheophorbide-d methyl ester as the starting material, by air oxidation, Knoevenagel reaction, Hener reaction, Tiffeneau-Demjanov rearrangement, Friedlaender condensation and reduction and other chemical reactions to the chemical modification of its carbonyl and carbonyl carbonyl, in C (3) - and external E- to establish a different chemical structure, a series of synthesis with The chlorin derivatives with basic structure of chlorophyll are discussed, and the relationship between the molecular structure and UV-Vis spectra is discussed, and the possible reaction mechanism is proposed for the corresponding chemical reactions.The newly reported chemical structures of chlorophyll derivatives It was confirmed by UV, IR, 1H NMR and elemental analysis.