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目的 通过对植物活性单体环维黄杨星D的结构改造 ,以寻求疗效更好、治疗安全范围更宽的心血管药物。方法 根据合理药物设计原理 ,设计合成目标化合物 ,并研究其生物活性。结果 获得 1 0个环维黄杨星D新衍生物 ,经光谱证明了结构。结论 选取部分环维黄杨星D新衍生物进行耐缺氧、抗心律失常药理实验 ,结果表明部分化合物药理活性优于环维黄杨星D。
OBJECTIVE: Through the structural modification of the plant-active monomer Cyclovirobuxine D to seek cardiovascular drugs with better curative effects and a wider therapeutic safety range. Methods According to rational drug design principles, the target compound was designed and synthesized, and its biological activity was studied. RESULTS: 10 new derivatives of Cyclovirobuxine D were obtained and their structures were confirmed by spectra. Conclusion Selecting some new derivatives of Cyclovirobuxine D for pharmacological experiments against hypoxia and anti-arrhythmia, the results showed that the pharmacological activity of some compounds was superior to that of Cyclovirobuxine D.