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对27例慢性肾功能衰竭(CRF)患者和27例正常人,空腹及葡萄糖餐后血清中的生长激激素(GH)水平,进行了测定。结果显示:CRF患者空腹及试餐后GH均高于正常组(P<0.05),多数患者试餐后出现GH“反向升高”。耐糖正常与耐糖减低的CRF患者血清GH差异无显著性。同种异体肾移植后,血清GH水平低于肾移植前(P<0.05),且“反向升高”现象消失。本文初步探讨了CRF患者血清GH升高的机理,以及GH异常与耐糖减低的关系。
The fasting and postprandial serum GH levels were measured in 27 patients with chronic renal failure (CRF) and 27 healthy individuals. The results showed that: GH in fasting and postprandial GH in CRF patients were significantly higher than those in normal controls (P <0.05); There was no significant difference in serum GH between CRF patients with normal glucose tolerance and glucose tolerance. After allogeneic kidney transplantation, the level of serum GH was lower than that before kidney transplantation (P <0.05), and the phenomenon of “reverse increase” disappeared. This article initially explored the mechanism of elevated serum GH in patients with CRF, and the relationship between GH abnormalities and glucose tolerance.