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Quninuclidinyl-benzilate (QNB) has long been recognized as a competitive antagonist of muscarinic acetylcholine receptors, while its effects on brain nicotinic acetylcholine receptors were not examined. The results of our preliminary experiments indicated that iv QNB in rats could prevent EEG seizures induced by nicotine 1.0 mg/kg iv. The purpose of this experiment is to examine the effects of QNB on brain nicotinic acetylcholine receptors. Intravenous injection of QNB COHld dose-dependcrltly prevent both behavioral convulsio/is and clonic—tonjc EEG-seizure discharges indaced by nicotine base at the dose of 1.0 mg/kg iv in mice.ED_(50)±CL_(95)=2.0±0.6mg/kgiv,b±S_b=2.8±0.5,r=0.94.The ED_(50) of QNB against nicotine-convulsions was twenty times of that of
Quninuclidinyl-benzilate (QNB) has long been recognized as a competitive antagonist of muscarinic acetylcholine receptors, while its effects on brain nicotinic acetylcholine receptors were not examined. The results of our preliminary experiments that that iv QNB in rats could prevent EEG seizures induced by nicotine 1.0 mg / kg iv. The purpose of this experiment is to examine the effects of QNB on brain nicotinic acetylcholine receptors. Intravenous injection of QNB COHld dose-dependcrltly prevent both behavioral convulsio / is and clonic-tonjc EEG-seizure discharges indaced by nicotine base the dose of 1.0 mg / kg iv in mice. ED_ (50) ± CL_ (95) = 2.0 ± 0.6 mg / kgiv, b ± S_b = 2.8 ± 0.5, r = 0.94.The ED_ (50) of QNB against nicotine -convulsions was twenty times of that of