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目的:探讨地佐辛用于腹腔镜手术后的镇痛效果及其对炎性因子的影响。方法:选取临海市第一人民医院2017年5月至2019年12月择期行腹腔镜手术患者86例，按照随机数字表法分为对照组（n n=43）和观察组（n n=43），两组患者在手术完成前15 min静脉输入镇痛液，对照组镇痛液为舒芬太尼+氟比洛芬酯+昂丹司琼。观察组在对照组基础上加地佐辛。比较两组术前、术后48 h血清肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）、丙二醛（MDA）、超氧化物歧化酶（SOD）水平变化，比较两组术后2 h、术后12 h、术后24 h的疼痛程度及不良反应发生情况。n 结果:术前，两组TNF-α、IL-6、MDA、SOD均差异无统计学意义（均n P>0.05）；术后48 h，观察组TNF-α［（28.92±3.47）pg/L］、IL-6［（67.81±8.14）pg/L］、MDA［（6.37±0.96）mmol/L］均低于对照组［（44.59±4.90）pg/L、（133.52± 17.36）pg/L、（10.12±1.21）mmol/L，SOD［（78.35±10.97）U/mL］高于对照组［（57.34±7.45）U/mL］，均差异有统计学意义（n t=17.114、22.473、15.921、-10.390，均n P<0.05）。观察组术后2 h、术后12 h、术后24 h疼痛评分分别为（1.05±0.61）分、（2.25±0.60）分、（1.72±0.62）分，均低于对照组的（1.36±0.48）分、（3.12±0.54）分、（2.37±0.71）分（n t=2.619、7.067、4.522，均n P<0.05）。观察组恶心、呕吐发生率分别为4.65% （2/43）、0.00%（0/43），均低于对照组的20.93%（9/43）、13.95%（6/43），均差异有统计学意义（χn 2=5.108、4.479，均n P 0.05). At 48 hours after surgery,tumor necrosis factor-alpha [(28.92 ± 3.47) pg/L], interleukin-6 [(67.81 ± 8.14) pg/L] and malondialdehyde [(6.37 ± 0.96) mmol/L] levels in the observation group were significantly lower compared with the control group [(44.59 ± 4.90) pg/L, (133.52 ± 17.36) pg/L, (10.12 ± 1.21) mmol/L, n t = 17.114, 22.473, 15.921, n P < 0.05]. At 48 hours after surgery,superoxide dismutase level in the observation group was significantly higher than that in the control group [(78.35 ± 10.97) U/mL n vs. (57.34 ± 7.45) U/mL,n t = -10.390, n P < 0.05). At 2, 12 and 24 hours after surgery, pain score in the observation group (1.05 ± 0.61 points, 2.25 ± 0.60 points, 1.72 ± 0.62 points, respectively) were significantly lower compared with the control group (1.36 ± 0.48) points, (3.12 ± 0.54) points, (2.37 ± 0.71) points, n t = 2.619, 7.067, 4.522, all n P < 0.05). The incidences of nausea and vomiting in the observation group were significantly lower compared with the control group [nausea:4.65% (2/43) n vs. 20.93% (9/43), vomiting: 0.00% (0/43) n vs. 13.95% (6/43), χn 2= 5.108 and 4.479, both n P < 0.05).n Conclusion:Dezocine for analgesia after laparoscopic surgery can reduce the degree of pain,inhibit postoperative inflammatory reaction and oxidative stress reaction,and reduce the incidence of adverse reactions.