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目的 :探讨乳腺癌中P5 3、C -erbB - 2基因蛋白及雌激素受体 (ER)、孕激素受体 (PR)的表达及其临床病理意义。方法 :应用S -P方法 ,对 75例乳腺癌及乳腺良性病变组织进行了P5 3、C -erbB - 2、ER、PR检测。结果 :在 75例乳腺癌及乳腺良性病变组织标本中P5 3、C -erbB - 2、ER、PR的阳性表达率分别为乳腺单纯癌 6 0 %、70 %、85 %、80 % ,导管内癌 33.3%、5 5 .6 %、4 4 .4 %、4 4 .4 % ,浸润性导管癌 6 6 .7%、72 .2 %、72 .2 %、6 6 .7% ,粘液腺癌5 0 %、6 6 .7%、5 0 %、5 0 % ,髓样癌 5 7.1%、71.1%、71.1%、5 7.1% ,乳腺良性病变 0 0 .0 %、33.3%、4 6 .7%、4 0 %。乳腺癌组织与乳腺良性病变组织相比较 ,二者差异显著 (P <0 .0 5 )。在浸润型与非浸润型之间比较差异均无显著性(P >0 .0 5 )。结论 :P5 3、C -erbB - 2基因蛋白及ER、PR联合检测有利于更好地评估乳腺癌的生物学行为 ,对乳腺癌术后治疗方案有着重要的指导意义。
Objective: To investigate the expression of P53 and C-erbB-2 gene and the expression of estrogen receptor (ER) and progesterone receptor (PR) and their clinicopathological significance in breast cancer. Methods: P5 3, C-erbB-2, ER and PR were detected in 75 cases of breast cancer and benign breast lesions using S-P method. Results: The positive rates of P53, C-erbB-2, ER and PR in 75 specimens of breast cancer and benign breast lesions were 60%, 70%, 85% and 80% Cancer 33.3%, 55.6%, 44.4%, 44.4%, invasive ductal carcinoma 6 6 .7%, 72 .2%, 72 .2%, 66.7%, mucinous gland The percentages of cancers 50%, 66.7%, 50%, 50%, medullary carcinoma 5 7.1%, 71.1%, 71.1%, 51.1%, benign breast lesions were 0.0%, 33.3% .7%, 40%. The difference between breast cancer tissue and benign breast lesions was significant (P <0.05). There was no significant difference between infiltrative and non-infiltrative (P> 0.05). Conclusion: The combination of P5 3, C - erbB - 2 gene protein and ER, PR detection is helpful to evaluate the biological behavior of breast cancer better and has important guiding significance for postoperative treatment of breast cancer.