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目的:探讨肝细胞癌切除术后复发患者采用射频消融术(RFA)治疗的临床效果。方法:选取2008—2012年收治的97例肝细胞癌切除术后复发患者作为观察对象,其中再次治疗采用射频消融术者58例(射频组)、选择采用无水酒精注射治疗者39例(无水酒精组),比较两组肿瘤复发治疗效果。结果:病灶≤3 cm和>3 cm者,射频组的治疗次数均低于无水酒精组,差异有统计学意义(P<0.05);病灶≤3 cm者,射频组灭活率为90.24%,无水酒精组为80.00%,组间比较无统计学差异(P>0.05);病灶>3 cm者,射频组病灶灭活率明显高于无水酒精组(82.61%vs.50.00%,P<0.05)。射频组并发症率低于无水酒精组但无统计学差异(31.03%vs.41.03%,P>0.05);射频组末次治疗后的1、2、3年存活率分别为84.48%、62.07%、43.01%均明显高于无水酒精组的64.10%、42.03%、20.51%,差异均有统计学意义(P<005);射频组总生存中位时间明显长于无水酒精组(18个月vs.13个月,Log-rankχ2=5.566,P=0.018)。结论:肝细胞癌切除术后复发采用射频消融术治疗临床疗效良好。
Objective: To investigate the clinical effect of radiofrequency catheter ablation (RFA) in patients with recurrent hepatocellular carcinoma after resection. Methods: A total of 97 patients with recurrence of hepatocellular carcinoma (HCC) who underwent resection between 2008 and 2012 were enrolled in this study. Among them, 58 (radio frequency group) patients treated by radiofrequency ablation were treated again, and 39 patients treated by anhydrous alcohol injection Water alcohol group), compare the two groups of tumor recurrence treatment effect. Results: The frequency of treatment in RF group was lower than that in anhydrous alcohol group (P <0.05), and the frequency of RF group was 90.24% (P> 0.05). In the group of> 3 cm, the inactivation rate in RF group was significantly higher than that in the group of anhydrous alcohol (82.61% vs. 50.00%, P <0.05). The complication rate of radiofrequency group was lower than that of anhydrous alcohol group (31.03% vs.41.03%, P> 0.05). The survival rates at 1, 2 and 3 months after radiotherapy group were 84.48% and 62.07% , 43.01% were significantly higher than 64.10%, 42.03% and 20.51% in anhydrous alcohol group, the difference was statistically significant (P <005); the total survival time of RF group was significantly longer than that of anhydrous alcohol group (18 months vs 13 months, Log-rank 2 = 5.566, P = 0.018). Conclusion: The recurrence of hepatocellular carcinoma with radiofrequency ablation is a good clinical treatment.