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1-氟-2,4-二硝基苯(缩写FDNB),亦称2,4-二硝基-1-氟苯(缩写DNFB),为淡黄色固体,26℃时则熔成可水溶性的粘稠液体。自从1945年以来一直用作蛋白质的氨基、氨基酸及其衍生物的示踪剂。也被用作价格昂贵的2,4-二硝基-1-氯苯(DNCB)的代用品,而用于免疫机制的研究。一、毒性FDNB可使皮肤染黄,最明显的毒效应是对皮肤的致敏作用,同时也是一种很强的原发性刺激剂。这种原发性刺激作用于网状内皮系统能起到一种类似佐剂的效应,因而又加强其
1-Fluoro-2,4-dinitrobenzene (abbreviated as FDNB), also known as 2,4-dinitro-1-fluorobenzene (abbreviated as DNFB), is a pale yellow solid that melts into a water-soluble Viscous liquid. Has been used as a tracer of amino acids, amino acids and their derivatives of proteins since 1945. Is also used as a substitute for the expensive 2,4-dinitro-1-chlorobenzene (DNCB) for the study of immune mechanisms. First, the toxicity FDNB can make the skin yellow, the most obvious toxic effects on the skin sensitization, but also a strong primary irritant. This primary stimulus acts on the reticuloendothelial system to act like an adjuvant, reinforcing it again