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本实验观察了生大黄对46只大鼠离体肠管电活动和收缩活动的影响,从电生理角度对其泻下和收剑机制作了初步探讨,结果表明:大黄对整个结肠电活动有明显兴奋作用,兴奋的特点为群集性放电,峰电频率明显增快(51.4±12.31C/min),幅度明显增高(2.8±0.49mv,p<0.01)。小剂量大黄可使肠电抑制,大剂量使则肠电兴奋。大黄也可使十二指肠峰电频率增快(由12.3±4.64C/min,增加到22.5±9.68C/min.)。阿托品可阻断大黄对肠管的兴奋效应,提示大黄是通过作用于肠管中M受体而实现其泻下作用的。
In this experiment, the effects of rhubarb on the electric activity and contraction activity of isolated intestine of 46 rats were observed. From the electrophysiological point of view, the mechanism of diarrhea and harvesting was discussed. The results showed that: rhubarb has obvious effect on the whole colonic electrical activity. Excitatory effects and excitement were characterized by cluster discharge, peak electrical frequency was significantly faster (51.4±12.31 C/min), and amplitude was significantly higher (2.8±0.49 mv, p<0.01). Small doses of rhubarb can inhibit intestinal electrical activity, and high doses cause bowel electrical activity. Rhubarb can also increase the frequency of duodenal peak (from 12.3±4.64C/min to 22.5±9.68C/min.). Atropine can block the stimulatory effect of rhubarb on the bowel, suggesting that rhubarb exerts its diarrhea effect by acting on the M receptor in the intestinal tract.