目的:探讨是否增加氯吡格雷维持剂量能增强对血小板聚集的抑制作用。方法和结果:60例经600mg氯吡格雷预治疗的患者在接受成功PCI术后12h内被纳入研究,以随机、双盲方式分为两组,分别接受氯吡格雷75mg/d或150mg/d治疗。PCI术后30d,分别采用光学聚集度测定和即时检测(VerifyNowTMP2Y12)方法测量血小板功能。 Objective: To investigate whether increasing clopidogrel maintenance dose can enhance the inhibitory effect on platelet aggregation. METHODS AND RESULTS: Sixty patients who were pretreated with 600 mg of clopidogrel were enrolled within 12 hours of their successful PCI and were randomized, double-blind, to receive either clopidogrel 75 mg / day or 150 mg / day treatment. Thirty days after PCI, platelet function was measured by optical concentration measurement and real-time detection (VerifyNowTMP2Y12).