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目的通过测定不稳定型心绞痛(unstable angina pectoris,UAP)患者心绞痛入院后及经正规治疗心绞痛缓解后血清高敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平的变化情况,以探讨其与心绞痛发作之间的关系。方法测定81例于本院诊断为不稳定型心绞痛患者入院后及经过治疗后病情相对稳定时的hs-CRP水平。并与同时期在门诊体检者中选取的健康对照组及稳定型心绞痛组进行比较。结果各组间hs-CRP水平:正常对照组(2.74±0.76)mg/L;稳定型心绞痛组(4.06±0.92)mg/L;治疗前组(7.64±2.03)mg/L;治疗后组(5.41±1.39)mg/L。治疗前组与正常对照组及稳定型心绞痛组比较差异均有统计学意义(P<0.01);治疗前后两组比较差异有统计学意义(P<0.05)。结论以上结果表明hs-CRP和UAP的发生有关系,所有心绞痛患者的hs-CRP水平均高于正常对照组,尤其在心绞痛发作时更是显著升高,hs-CRP可能在不稳定型心绞痛的发生、发展中起到一定的作用,早期干预可能会减少急性心血管事件的发生。
Objective To determine the changes of serum high-sensitivity C-reactive protein (hs-CRP) levels after admission of angina pectoris in patients with unstable angina pectoris (UAP) and after formal treatment of angina pectoris Explore its relationship with angina pectoris. Methods The hs-CRP levels of 81 patients diagnosed as unstable angina pectoris in our hospital after admission and after treatment were relatively stable. And compared with the healthy control group and stable angina pectoris group selected from outpatients during the same period. Results The levels of hs-CRP in each group were (2.74 ± 0.76) mg / L in normal control group and 4.06 ± 0.92 mg / L in stable angina pectoris group (7.64 ± 2.03) mg / L before treatment group 5.41 ± 1.39) mg / L. There was significant difference between pre-treatment group and normal control group and stable angina pectoris group (P <0.01). There was significant difference between the two groups before and after treatment (P <0.05). Conclusion The above results indicate that hs-CRP is associated with the occurrence of UAP. The hs-CRP level in all patients with angina pectoris is higher than that of the normal control group, especially in the episode of angina pectoris, hs-CRP may be in unstable angina pectoris Occurrence and development play a role, early intervention may reduce the occurrence of acute cardiovascular events.