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目的探讨神经降压素（ＮＴ）在肺组织内的分布及临床意义。②方法采用免疫组织化学ＳＰ法对４３例肺癌病人肿瘤组织中ＮＴ进行了标记。③结果４３例肺癌组织中ＮＴ阳性率为６７％，其阳性颗粒主要分布于癌细胞胞浆内，部分分化较高的腺癌可见顶浆分泌型颗粒，其中小细胞癌及腺癌阳性率明显高于鳞状细胞癌（χ２＝１０．８，Ｐ＜０．０１）。④结论肺癌组织可合成、分泌ＮＴ，且其在肺癌分化的判定及肺癌诊断中具有一定的应用价值
Objective To investigate the distribution and clinical significance of neurotensin (NT) in lung tissue. 2 Methods Immunohistochemical SP method was used to label NT in tumor tissues of 43 patients with lung cancer. 3 Results The positive rate of NT was 67% in 43 cases of lung cancer. The positive particles were mainly distributed in the cytoplasm of cancer cells. Part of the differentiated adenocarcinoma showed apical secretory granules. The positive rate of small cell carcinoma and adenocarcinoma was significant. Higher than squamous cell carcinoma (χ2=10.8, P<0.01). 4 Conclusions Lung cancer can synthesize and secrete NT, and it has certain application value in the determination of lung cancer differentiation and diagnosis of lung cancer.