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探讨胎盘型谷胱甘肽S -转移酶 (GST -π)和 p5 3蛋白在肾癌中表达的临床病理意义和相关性。方法 :应用LSAB免疫组化法对 43例肾癌GST -π和 p5 3蛋白的表达进行研究。结果 :肾癌中GST -π和p5 3蛋白的阳性率分别为 6 0 .47%和 32 .5 6 %。GST -π表达与肿瘤分化程度明显相关 ,高中分化肾癌阳性率明显高于低分化者(P <0 .0 5 )。GST -π与p5 3蛋白表达呈明显正相关 (r =0 .375 ,P <0 .0 5 ) ,p5 3蛋白阳性者中GST -π阳性率高于p5 3蛋白阴性者。结论 :GST -π异常表达可能与肾癌的发生、发展及其化疗耐药性有关。检测GST -π表达对预测肾癌多药耐药、化疗疗效有一定的价值。
To investigate the clinicopathological significance and correlation of placental glutathione S-transferase (GST-π) and p5 3 protein expression in renal cell carcinoma. Methods: The expressions of GST-π and p53 protein in 43 cases of renal cell carcinoma were studied by LSAB immunohistochemistry. Results: The positive rates of GST-π and p5 3 in renal cell carcinoma were 60.47% and 32.56%, respectively. The expression of GST-π was significantly correlated with the degree of tumor differentiation, and the positive rate of high differentiation kidney cancer was significantly higher than that of poorly differentiated (P <0.05). The positive expression rate of GST-π was positively correlated with the expression of p5 3 protein (r = 0.375, P <0.05). The positive rate of GST-π in p5-3 protein positive group was higher than that of p5-3 protein. Conclusion: Abnormal expression of GST-π may be related to the occurrence and development of renal cell carcinoma and its chemoresistance. Detection of GST-π expression on the prediction of multi-drug resistance of renal cell carcinoma, chemotherapy has a certain value.