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目的比较小剂量米索前列醇和缩宫素在足月引产中的效果和安全性。方法前瞻性选择2012年1月至2013年1月符合引产指征的单胎足月妊娠孕产妇120例,按随机数字法分为两组,A组60例孕产妇引产前给予米索前列醇25μg置于阴道后穹窿处,B组60例给予静脉滴注缩宫素2.5 U。结果 A组产妇在给药后8 h Bishop评分、临产时间、诱发宫缩时间和总产程方面均显著优于B组(P<0.05),A组总有效率达83.3%,显著高于B组的56.7%,差异有统计学意义(P<0.05)。两组顺产率分别为93.3%和65.0%,差异有统计学意义(P<0.05)。两组在产后出血量、新生儿窒息和新生儿Apgar评分方面比较差异无统计学意义(P>0.05),且均未见严重不良反应。结论两种药物各具特色,其中米索前列醇效果更显著,能显著缩短临产时间和产程,提高顺产率,值得推广。
Objective To compare the efficacy and safety of low-dose misoprostol and oxytocin in term-term labor induction. Methods 120 cases of singletonic full-term pregnant women who met the induction of labor induction were prospectively selected from January 2012 to January 2013 and divided into two groups according to random number method. A group of 60 pregnant women were given misoprostol 25μg placed in the vaginal posterior fornix, B group 60 patients given intravenous infusion of oxytocin 2.5U. Results The Bishop score, time to labor, duration of induced contractions and total labor duration in group A were significantly better than those in group B at 8 h (P <0.05). The total effective rate in group A was 83.3%, significantly higher than that in group B Of 56.7%, the difference was statistically significant (P <0.05). The two groups of birth rates were 93.3% and 65.0%, the difference was statistically significant (P <0.05). There was no significant difference in postpartum hemorrhage, neonatal asphyxia and neonatal Apgar score between the two groups (P> 0.05), and no serious adverse reactions were found. Conclusion The two drugs have their own characteristics, including misoprostol effect is more significant, can significantly reduce the labor time and labor process, improve the yield, is worth promoting.