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目的探讨消化系统恶性肿瘤患者临终前血小板和白细胞数突变与预后的关系。方法观察175例消化系统恶性肿瘤患者死亡前1～3 d与4～7 d血小板(PLT)和白细胞(WBC)数的变化,应用SPSS11.0统计软件进行分析。结果患者死亡前1～3 d PLT明显低于死亡前4～7 d的水平,差异有统计学意义(P<0.05);死亡前1～3 dWBC明显高于4～7 d的水平,差异有统计学意义(P<0.05)。结论消化系统肿瘤患者临终前1～3 d内PLT迅速下降,WBC数迅速升高,是病情迅速恶化的征兆。这种现象警示严重预后不良,死亡风险增加。
Objective To investigate the relationship between the number of pre-termination platelet and leukocyte mutation and prognosis in patients with digestive system malignant tumor. Methods The changes of platelet (PLT) and white blood cell (WBC) count of 1 ~ 3 d and 4 ~ 7 d before death in 175 patients with digestive system malignant tumor were observed and analyzed by using SPSS11.0 statistical software. Results The PLT of patients 1 ~ 3 days before death was significantly lower than that of 4 ~ 7 days before death, the difference was statistically significant (P <0.05); the WBC 1 ~ 3 d before death was significantly higher than that of 4 ~ 7 d Statistical significance (P <0.05). Conclusions The rapid decline of PLT and the rapid increase of WBC number within 1 ~ 3 d before the death of digestive system cancer patients are signs of the rapid deterioration of the disease. This phenomenon indicates serious adverse prognosis and increased risk of death.