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目的探讨血清胆汁酸、胆碱酯酶检测在肝病患者诊断中的临床应用价值。方法选取2012年1月至2014年12月我院收治的100例肝病患者作为研究对象,将其设置为观察组,另选取100例同期在我院进行体检的健康体检者作为对照组,对肝病患者和健康体检者进行检测,检测指标主要为血清胆汁酸、胆碱酯酶以及谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBIL)、谷氨酰转肽酶(GGT)。结果与对照组相比,观察组患者血清中胆汁酸的含量明显更高(P<0.05),且急性肝病患者的血清胆汁酸的含量明显高于慢性肝病患者(P<0.05);观察组患者血清中的胆碱酯酶的含量明显更低(P<0.05),且急性肝病患者的胆碱酯酶的含量明显低于慢性肝病患者(P<0.05)。结论在肝病患者的临床诊断中,在常规肝功能检测的基础上,对患者进行血清胆汁酸、胆碱酯酶检测,能够提高肝病患者的确诊率,对肝病的鉴别诊断具有十分重要的意义。
Objective To investigate the clinical value of serum bile acid and cholinesterase in the diagnosis of liver disease. Methods 100 cases of liver disease admitted from January 2012 to December 2014 in our hospital were selected as the observation group and 100 cases were selected as healthy subjects for physical examination in our hospital as the control group. Patients and healthy people were tested. Serum bile acid, cholinesterase, ALT, AST, TBP, ALP, TBIL, Glutamyl transpeptidase (GGT). Results Compared with the control group, serum bile acids in the observation group was significantly higher (P <0.05), and serum bile acid levels were significantly higher in patients with acute liver disease than those in patients with chronic liver disease (P <0.05). Patients in the observation group Serum cholinesterase levels were significantly lower (P <0.05), and patients with acute liver disease cholinesterase levels were significantly lower than those of patients with chronic liver disease (P <0.05). Conclusions In the clinical diagnosis of patients with liver disease, based on routine liver function tests, serum bile acids and cholinesterase detection can improve the diagnosis rate of patients with liver diseases, which is of great significance in the differential diagnosis of liver diseases.