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通过强制冷水游泳应激模拟慢性疲劳的发病过程。结果表明，强制冷水游泳应激使大鼠自发活动减少，出现抑郁倾向，力竭游泳时间缩短，体力下降，血清中肾上腺素（Ｅ）、多巴胺（ＤＡ）、５羟色胺（５ＨＴ）含量升高，肾上腺抗坏血酸含量降低，这些与慢性疲劳患者症状表现和实验室检查结果相似。以补气理气、调理肝脾为组方原则的中药复方“消疲怡神口服液”可以调节上述变化，表明其具有抗应激、抗疲劳作用，同时该结果还为研究中医气机失调、肝脾失和与应激、慢性疲劳的关系提供了理论依据
Simulate the pathogenesis of chronic fatigue by strong cooling water swimming stress. The results showed that the strong cold water swimming stress reduced the spontaneous activity of rats, led to the tendency of depression, shortened exhausted swimming time, decreased physical strength, and serum epinephrine (E), dopamine (DA), serotonin (5 HT) content Elevated adrenal ascorbate levels are reduced, these are similar to the results of the symptoms and laboratory tests in patients with chronic fatigue. The traditional Chinese medicine compound “Xiwei Yishen Oral Liquid” with the principle of qi and qi and conditioning liver and spleen can regulate the above changes, indicating that it has anti-stress and anti-fatigue effects. At the same time, this result is also used to study the imbalance of TCM qi. The relationship between liver and spleen loss and stress, chronic fatigue provides a theoretical basis