Two-dimensional surface-enhanced Raman scattering (SERS) substrates have drawn intense attention due to their excellent spectral reproducibility,high uniformity and perfect anti-interference ability.However,the infe-rior detection sensitivity and low enhancement have limited the practical application of two-dimensional SERS substrates.To address this issue,we propose that the interaction between the MoTe2 substrate and the analyte rhodamine 6G molecules could be remarkably enhanced by the introduced p-doping effect and lattice distortion of MoTe2 via hydrogen plasma treatment.After the treatment,the SERS is greatly improved,the enhancement factor of probe molecules reaches 1.83 × 106 as well as the limit of detection concentration reaches 10-13 M.This method is anticipated to afford new enhancement probability for other 2D materials,even non-metal oxide semiconductor SERS substrates.