3α-和3β-本胆烷醇酮(1和2)可用于治疗再生障碍性贫血,目前已有商品出售,但价格较昂贵.文献报道该两种化合物在合成中因反应选择性差,故收率较低.本实验以睾丸素(3)为原料,合成了这两个化合物.在合成方法上进行了一些改进,避免了原料的回收,提高了产率,其合成路线如下. 3α- and 3β-present cholecalcone (1 and 2) can be used for the treatment of aplastic anemia, the current sale of goods, but the price is more expensive reported in the literature because of the two compounds in the synthesis of poor selectivity, so close The test is based on the testosterone (3) as raw materials, the two compounds were synthesized in the synthesis method to make some improvements to avoid the recovery of raw materials to improve the yield, the synthetic route is as follows.