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据Ｐａｉｎ[1999,83 ( 3 ) :63 1]载 美国Ｙｕａｎ等评价了一种外周类阿片受体拮抗剂甲基纳曲酮 (ｍｅｔｈｙｎａｌｔｒｅｘｏｎｅ)对 4例慢性美沙痛性便秘的病人的慢性类阿片性肠蠕动变化的作用。这是一项单盲安慰剂对照的研究 ,共进行 8天。第 1天给安慰剂 ;其余各天给静脉
According to Pain [1999,83 (3): 63 1], Yuan et al. Evaluated the peripheral opioid receptor antagonist methynaltrexone against chronic opioidosis in 4 patients with chronic pain-related constipation Changes in the role of intestinal motility. This is a single blind placebo-controlled study for 8 days. Day 1 for placebo; the remaining days for veins