周围神经毒性是奥沙利铂的临床剂量限制性毒性,随着对其机制的认识,临床上已有一些预防和治疗其毒性的药物,目前报道有预防和治疗作用的药物有镁盐、钙盐、卡马西平、阿米硫定、谷胱甘肽和加巴喷丁等。现就奥沙利铂神经毒性临床预防和治疗药物的进展做一综述。 Peripheral neurotoxicity is the clinical dose-limiting toxicity of oxaliplatin. With the understanding of its mechanism, some drugs have been clinically proven to prevent and treat its toxicity. Currently, there are reports on the preventive and curative effects of magnesium salt, calcium Salt, carbamazepine, amifostine, glutathione and gabapentin. The progress of the clinical prevention and treatment of oxaliplatin neurotoxicity is reviewed.