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研究了慢性肾功能不全(CRI)患者血浆载脂蛋白A_1、B浓度与肾功能的关系。方法:将45例CRI患者按肾功能分为3组,检测其血浆apoA_1和apoB浓度,并与健康对照组比较。结果:CRI患者的血浆apoA_1浓度显著低于对照组(P<0.01),且肾功能越低,降低越显著(P<0.01),apoB浓度及apoB/apoA_1,显著高于对照组(P<0.01),且肾功能越低,升高越显著(P<0.01)。结论:CRI患者存在动脉硬化倾向,且随肾功能减退加重,这种倾向更加明显。
To investigate the relationship between plasma apolipoprotein A_1, B concentrations and renal function in patients with chronic renal insufficiency (CRI). Methods: 45 CRI patients were divided into 3 groups according to their renal function. The concentrations of apoA_1 and apoB in plasma were measured and compared with those in healthy control group. Results: The plasma apoA_1 levels in patients with CRI were significantly lower than those in the control group (P <0.01), and the lower the renal function was, the more significant the decrease was (P <0.01). The apoB concentrations and apoB / apoA_1 were significantly higher than those in the control group ), And lower renal function, the more significant increase (P <0.01). CONCLUSIONS: There is a predisposition to arteriosclerosis in patients with CRI, and this tendency becomes more pronounced as renal dysfunction worsens.