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目的观察达菲林联合妈富隆治疗重度子宫内膜异位症(EMS)的临床效果及安全性。方法选取医院收治的重度EMS患者50例,随机分为M组25例和M+D组25例。M组单纯应用妈富隆治疗,M+D组应用达菲林联合妈富隆治疗。比较2组重度EMS治疗效果,观察治疗期间并发症发生率,比较干预前和半年后患者性激素水平FSH、LH、E2和子宫腺病灶大小的差异。结果 M+D组治疗总有效率为96.00%,显著高于M组的80.00%(P<0.01);2组治疗期间并发症发生率比较差异无统计学意义(P>0.05)。半年后,2组性激素水平FSH、LH、E2和子宫腺病灶大小较干预前均改善,且M+D组较M组改善更显著,差异均有统计学意义(P<0.05)。结论达菲林联合妈富隆治疗重度EMS临床效果及安全性高,可有效改善患者性激素水平和缩小病灶,无明显不良反应,安全性高,值得推广应用。
Objective To observe the clinical effect and safety of combination of diphenhydramine and Marvelon in the treatment of severe endometriosis (EMS). Methods Fifty patients with severe EMS admitted to hospital were randomly divided into 25 cases in M group and 25 cases in M + D group. The M group was treated with Marvelon alone, and the M + D group was treated with Tamiflu combined with Marvelon. The therapeutic effects of severe EMS were compared between two groups. The incidence of complications during treatment was observed. The differences of sex hormone levels FSH, LH, E2 and the size of uterine gland lesions between the two groups before and after intervention were compared. Results The total effective rate of M + D group was 96.00%, which was significantly higher than that of M group (80.00%, P <0.01). There was no significant difference in the complication rates between the two groups (P> 0.05). Six months later, FSH, LH, E2 and uterine gland lesions of 2 groups of sex hormones were improved compared with that before intervention, and M + D group had more significant improvement than M group (P <0.05). Conclusion Tamiflu combined Marvelon treatment of severe clinical efficacy and high EMS, can effectively improve the level of patients with sex hormones and reduce the size of the lesion, no significant adverse reactions, high safety, it is worth promoting the application.