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骆驼蓬系蒺藜科骆驼蓬属多年生草本植物Peganum Harmala L。新疆医学院附属第二医院将骆驼蓬粗制剂用于治疗消化道肿瘤,初步观察认为有一定疗效,并有改善临床症状的作用。据文献了解,骆驼蓬种子中含有多种生物碱,主要为去氢骆驼蓬碱(Harmine),骆驼蓬碱(Harmaline),哈梅醇(Harmalol)和哈尔满(Harman)等。我室从该植物种子提取出多种生物碱,均为吲哚类生物碱,对其中混合生物碱5L、5N进行了体内、外抗肿瘤试验;现从骆驼蓬种子中分得去氢骆驼蓬碱,其抗肿瘤作用过去未见有报导。为探讨其抗肿瘤作用,我们观察其对体外培养的Hela细胞的生长及DNA合成的抑制作用。
Camelopsis pedunculata is a perennial herb called Pegamum Harmala L. The Second Affiliated Hospital of Xinjiang Medical College will use coarse camel powder preparations for the treatment of digestive tract tumors. Initial observations suggest that there are certain curative effects, and there is a role in improving clinical symptoms. According to the literature, seeds of Peganum harmalarum contain various alkaloids, mainly Harmine, Harmaline, Harmalol and Harman. Our laboratory extracted a variety of alkaloids from the seed of the plant, which are all alkaloid alkaloids. We conducted in vitro and in vivo anti-tumor tests on the mixed alkaloids 5L and 5N. We now have hydrogenated camelbows from seeds of Peganum harmala. Alkali, its anti-tumor effect has not been reported in the past. To investigate its anti-tumor effect, we observed its inhibitory effect on the growth and DNA synthesis of Hela cells cultured in vitro.