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本研究以大鼠为动物模型，观察了缺硒或适硒大鼠感染肺炎支原体（ＭＰ）间质性肺炎的发病率，以及感染后灌喂亚硒酸钠对发病率的影响。选择３周龄断乳Ｗｉｓｔａｒ大鼠１５０只，在喂饲各自实验饲料４周后，用乙醚麻醉Ｂ、Ｃ、Ｄ、Ｅ组动物，滴鼻感染肺炎支原体（ＭＰ）菌液，Ｃ组在感染的同时，开始灌喂亚硒酸钠溶液（２Ｓｅμｇ／ｍｌ，每天灌喂剂量为１．５～２ｍｌ），持续１８天；Ｄ组在感染后第１１天灌喂亚硒酸钠溶液，持续７天；Ｂ组和Ｅ组自感染之日起，灌喂生理盐水１８天，Ａ组无感染。结果证明，适硒感染组支原体肺炎发病率低，适硒感染组和低硒感染同时补硒组严重肺炎例数和心肌损害例数均少于缺硒感染组。提示良好的硒营养状况可减少大鼠ＭＰ肺炎发病率，对感染时的心肌有保护作用；补硒可减轻病情和加速病变恢复
In this study, rats were used as animal models to observe the incidence of interstitial pneumonia (MP) infection in selenium-deficient or selenium-infected rats and the effect of sodium selenite on the incidence after infection. A total of 150 Wistar rats were weaned at 3 weeks of age. Four weeks after feeding the respective experimental diets, the animals in groups B, C, D and E were anesthetized with ether, and the mycoplasma pneumoniae (MP) At the same time, began to feed sodium selenite solution (2Seμg / ml, the daily dose of 1.5 ~ 2ml) for 18 days; D group was infected with sodium selenite solution on the 11th day for 7 Day; group B and group E were infused with saline for 18 days from the date of infection, and group A was non-infected. The results showed that the incidence of mycoplasma pneumonia was lower in the selenium-infected group, and the number of severe pneumonia and the number of myocardial damage in the selenium-contaminated group and selenium-contaminated selenium group were less than those in the selenium-deficient group. Prompt good selenium nutritional status can reduce the incidence of MP pneumonia in rats, myocardial protection during infection; selenium can reduce the disease and accelerate the recovery of the disease