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目的分析晚期非小细胞肺癌(NSCLC)预后相关因子,以判断病情、指导治疗。方法将107例NSCLC患者按中医辨证分型分为5型,部分患者采用中医药方法治疗,部分患者采用中西医结合方法治疗。采用卡卜兰-迈尔(Kaplan-Meier)方法进行生存分析,采用Cox回归分析进行晚期NSCLC的预后分析。结果5种中医分型的生存时间气虚痰湿型>气滞血瘀型>阴虚毒热型>气阴两虚型>热毒炽盛型,各中医证型的生存率相比较均具有显著性差异(P均<0.01)。中西医结合治疗比纯中医药治疗疗效好(P<0.05)。结论晚期NSCLC预后保护因子有治疗方法、CD4+、CD4+/CD8+、卡氏评分、辨证分型、疗程,预后危险因子有原发病灶、年龄、吸烟、CD8+、恶性胸水、上腔静脉综合征、脑转移、骨转移、临床分期、病理类型、TPA、CEA、CA125。
Objective To analyze the prognostic factors of advanced non-small cell lung cancer (NSCLC) in order to judge the condition and guide the treatment. Methods A total of 107 patients with NSCLC were divided into 5 types according to syndrome differentiation of TCM. Some patients were treated by traditional Chinese medicine. Some patients were treated by combination of TCM and Western medicine. Survival analysis was performed using the Kaplan-Meier method and Cox regression analysis was performed for prognostic analysis of advanced NSCLC. Results The survival time of five TCM syndromes was significantly higher than that of Qi deficiency and phlegm-dampness syndrome> qi stagnation and blood stasis syndrome> Yin and heat toxicity syndrome> Qi and Yin deficiency syndrome> heat toxicity syndrome, Difference (all P <0.01). Integrative Medicine than pure Chinese medicine treatment effect (P <0.05). Conclusion The prognostic factors of advanced NSCLC include treatment of CD4 +, CD4 + / CD8 +, Karnofsky score, differentiation of symptoms and signs, course of treatment and risk factors of prognosis with primary lesion, age, smoking, CD8 +, malignant pleural effusion, superior vena cava syndrome, Metastasis, Bone metastasis, Clinical stage, Pathological type, TPA, CEA, CA125