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目的对深圳市2003年-2012年神经管畸形(简称NTDs)的发生情况进行流行病学分析。方法基于深圳市出生缺陷监测数据,计算2003-2012年无脑畸形、脊柱裂、脑膨出逐年围生期发生率,单因素分析危险因素;计算2010-2012年包括28周前NTDs终止妊娠病例的总发生率。结果深圳市NTDs围生期发生率从2003年的5.91/万下降到2012年的2.20/万,呈显著性下降趋势,单因素分析:母亲低龄(<20岁)、流动人口、女孩、多胎、居住地区等是围生期NTDs的危险因素。孕母各年龄组(高龄组除外)、流动人口NTDs发生率10年间呈显著性下降趋势,计算2010-2012年包括28周前终止妊娠病例的NTDs总发生率为9.90/万,仅低龄孕母、流动人口、多胎是NTDs发生的高危因素。结论 2003-2012年深圳市围生期NTDs发生率呈显著下降趋势,产前筛查、产前诊断是主要影响因素。包括28周前终止妊娠病例使NTDs总发生率上升,预防重点人群是流动人口、低龄孕母。
Objective To analyze the epidemiological analysis of the occurrence of neural tube defects (NTDs) in Shenzhen City from 2003 to 2012. Methods The incidence of anencephaly, spina bifida and encephalocele perinatal period from 2003 to 2012 was calculated based on the monitoring data of birth defects in Shenzhen. The risk factors were analyzed by univariate analysis. The cases of termination of pregnancy with NTDs between 2010 and 2012 The overall incidence. Results The incidence of perinatal NTDs in Shenzhen dropped from 5.91 / million in 2003 to 2.20 / million in 2012, showing a significant downward trend. Univariate analysis showed that the mothers’ ages (<20 years old), floating population, girls, multiple births, Living area and other perinatal NTDs risk factors. The incidence of NTDs in floating population ten years was significantly decreased in all age groups (except for the senior group), and the total incidence of NTDs in the cases of termination of pregnancy between 2010-2012 and before 28 weeks was 9.90 / , Floating population, multiple births are risk factors for NTDs. Conclusion The incidence of perinatal NTDs in Shenzhen was significantly decreased from 2003 to 2012. Prenatal screening and prenatal diagnosis were the main influencing factors. Including 28 weeks before the termination of pregnancy cases so that the overall incidence of NTDs increased, prevention of key populations are mobile population, low-age pregnant mothers.