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目的评价序贯疗法根除幽门螺杆菌的效果和不良反应。方法选取本院消化内科住院或门诊70例Hp阳性的患者,随机分为序贯治疗组和对照组,治疗组给予10日序贯疗法,对照组给予标准三联疗法,疗程10日,疗程结束后4周行快速尿素酶试验和银染色。结果治疗组的Hp根除率明显优于对照组(P<0.05),治疗组的快速尿素酶试验和银染色的转阴率分别为91.4%和82.3%,两组比较差异具有显著性(P<0.05)。结论序贯疗法根除Hp的效果好于标准三联疗法,副反应发生率低。
Objective To evaluate the efficacy and adverse reactions of sequential therapy in the eradication of Helicobacter pylori. Methods Seventy patients with Hp positive in inpatient or outpatient department of our hospital were randomly divided into sequential treatment group and control group. The treatment group was given sequential therapy on the 10th and the control group was given standard triple therapy. After the treatment was over, Four weeks of rapid urease test and silver staining. Results The Hp eradication rate of the treatment group was significantly better than that of the control group (P <0.05). The rapid urease test and silver staining of the treatment group were 91.4% and 82.3% respectively, with significant difference between the two groups (P < 0.05). Conclusions Sequential therapy is better than standard triple therapy in the eradication of Hp, with a low incidence of side effects.