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目的评估临床药师干预对基层医院抗菌药物使用的效果,为促进基层医院合理使用抗菌药物提供参考依据。方法以长沙市岳麓区某基层医院为研究对象,采用前后对照方法,对基层医院2012年8月至10月(干预前)291份病历和2013年3月至5月(干预后)301份病历抗菌药物使用的成本和效果进行分析。结果该基层医院抗菌药物使用合理率干预后由40%上升为93%(P<0.01),抗菌药物的使用率由>90%下降到<55%,差异显著(P<0.01);抗菌药物使用强度由>85DDD下降至约40 DDD(P<0.01),达到卫生部规定的标准,抗菌药物人均费用明显降低。结论临床药师系统干预有利于提高基层医院抗菌药物的合理使用,效果明显。
Objective To evaluate the effect of clinical pharmacist intervention on the use of antibacterials in primary hospitals and provide reference for rational use of antibacterials in primary hospitals. Methods Taking a grass-roots hospital in Yuelu District of Changsha as the research object, 291 medical records of primary hospitals from August to October 2012 (before intervention) and 301 medical records from March to May 2013 (after intervention) Antimicrobial use of the cost and effectiveness of the analysis. Results The rate of antimicrobial use decreased from 40% to 93% (P <0.01), and the rate of use of antibacterials decreased from> 90% to <55% (P <0.01) The intensity decreased from> 85DDD to about 40 DDD (P <0.01), meeting the standards prescribed by the Ministry of Health. The per capita cost of antimicrobial drugs was significantly reduced. Conclusion Clinical pharmacist system intervention is conducive to improving the rational use of antibacterial drugs in primary hospitals, the effect is obvious.