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BACKGROUND AND PURPOSE-In this study we compared risk factors,clinical features,and stroke recurrence in a large series of patients with large subcortical,cortical,or small deep infarcts.METHODS-Patients with a transient or minor ischemic attack(modified Rankin Scale grade of ≤3)who had a single relevant supratentorial infarct of presumed noncardioembolic origin on CT were classified as suffering from a large subcortical(n=120),small deep(n=324),or cortical(n=211)infarct.Mean follow-up was 8 years.Rates of recurrent stroke were compared with Cox regression.RESULTS-The clinical deficits caused by large subcortical infarcts resembled either those of a cortical or those of a small deep infarct.Risk factor profiles were similar in the 3 groups.The rate of recurrent stroke in patients with a large subcortical infarct(25/120;21%)did not differ from that of patients with a cortical infarct(46/211;22%)or with a small deep infarct(60/324;19%).After adjustment for age,sex,and vascular risk factors,hazard ratios for recurrent stroke of large subcortical and cortical infarcts were 1.05(95%CI,0.65 to 1.70)and 1.17(95%CI,0.79 to 1.73),respectively,compared with small deep infarcts.CONCLUSIONS-Clinical features,risk factor profiles,and stroke recurrence rate in patients with a large subcortical infarct only differ slightly from those in patients with small deep or cortical infarcts.
BACKGROUND AND PURPOSE-In this study we compared risk factors, clinical features, and stroke recurrence in a large series of patients with large subcortical, cortical, or small deep infarcts. METHHODS-Patients with a transient or minor ischemic attack (modified Rankin Scale grade of ≤ 3) who had a single relevant supratentorial infarct of presumed noncardioembolic origin on CT were classified as suffering from a large subcortical (n = 120), small deep (n = 324), or cortical (n = 211) infarct. -up was 8 years. Rtes of recurrent stroke were compared with Cox regression .RESULTS-The clinical deficits caused by large subcortical infarcts resembled either those of a cortical or those of a small deep infarct. Disk factor profiles were similar in the 3 groups. The rate of recurrent stroke in patients with large subcortical infarct (25/120; 21%) did not differ from that of patients with a cortical infarct (46/211; 22%) or with a small deep infarct (60/324; 19%). After adjustment for age, sex, and vascular risk fac tors, hazard ratios for recurrent stroke of large subcortical and cortical infarcts were 1.05 (95% CI, 0.65 to 1.70) and 1.17 (95% CI, 0.79 to 1.73), respectively, compared with small deep infarcts. CONCLUSIONS-Clinical features, risk factor profiles, and stroke recurrence rate in patients with a large subcortical infarct only differ slightly from those in patients with small deep or cortical infarcts.