近年来,以肥胖、糖尿病、脂代谢异常为代表的代谢性疾病在全球范围内不断增加,非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)的发病率也在逐年增加。NAFLD是一种肝脏病理生理变化的综合征,从肝脏脂质沉积到肝脏脂肪变性、纤维化、肝硬化,最终可发展为肝细胞癌。NAFLD疾病谱主要包括非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)及其相关的肝硬化和肝细胞癌。NAFLD的发病主要 In recent years, metabolic diseases such as obesity, diabetes and lipid metabolism have been increasing worldwide. The incidence of nonalcoholic fatty liver disease (NAFLD) has also been increasing year by year. NAFLD is a syndrome of pathophysiological changes in the liver, from the liver lipid deposition to hepatic steatosis, fibrosis, cirrhosis, eventually develop into hepatocellular carcinoma. The spectrum of NAFLD disease includes non-alcoholic simple fatty liver, nonalcoholic steatohepatitis (NASH) and its associated cirrhosis and hepatocellular carcinoma. The main pathogenesis of NAFLD