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Objective: To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction, and to provide new ideas for clinical treatment and prognosis evaluation. Methods: 60 patients with moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type from June 2017 to June 2019 were randomly divided into control group treated with conventional therapy and treatment group treated with Chaishao Chengqi Decoction for 2 weeks. The differences of clinical efficacy and TCM syndromes between the two groups were compared. Ranson score, Balthazar CTSI score, SIRS score and modified Marshall score were recorded before and after treatment. The levels of inflammatory factors and oxidative stress-related molecules were compared before and after treatment. Result:After treatment, the total effective rates of the control group and the treatment group were 80.0％and 93.3％, respectively, with statistical difference (χ2=8.845, P=0.027); after treatment, the total effective rates of TCM syndromes evaluation of the control group and the treatment group were 76.7％ and 93.3％, respectively, with statistical difference (χ2=10.024, P=0.012);after treatment, the Ranson score, Balthazar CTSI score, SIRS score and improved Marshall score were all significantly decreased (P<0.05), and the decrease was more significant in the treatment group (P<0.05); after treatment, the serum levels of TNF-α, IL-6 and MDA were significantly decreased in both groups, and superoxide dismutase (SOD) was significantly increased (P<0.05), and the treatment group improved more (P<0.05). Conclusion: Chaishao Chengqi Decoction has a good curative effect on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type, and can effectively improve inflammatory response and oxidative stress, which has a high clinical significance.