Blizzard等首先提出母亲自体免疫性甲状腺疾病(AITD),在新生儿甲状腺功能减退的发育中可能是主要病因。又发现已知或临床症状不显著的(亚临床)AITD妇女,娩出甲状腺功能减退新生儿,在母体血浆中存在具有多种生物活性的抗体。其中包括IgG:(1)抑制促甲状腺激素与其受体结合(TBllg);(2)抑制甲 Blizzard first proposed maternal autoimmune thyroid disease (AITD), may play a major role in the development of neonatal hypothyroidism. It was also found that women with known or clinically insignificant (subclinical) AITD had newborns with hypothyroidism and antibodies with multiple biological activities in their maternal plasma. Including IgG: (1) inhibition of thyrotropin binding to its receptor (TBllg); (2) inhibition of