在胚胎种植过程中,需要促炎因子与抗炎因子相互平衡,才能保证成功妊娠的建立与维持。子宫内膜炎或亚临床子宫内膜感染破坏了各因子之间的平衡状态,形成具有细胞和胚胎毒性的子宫内膜微环境,不利于精子成活和胚胎着床;引起炎症的病原体还可激发机体的免疫反应,产生大量致敏的活性细胞及多种细胞因子、炎性细胞,杀灭和吞噬精子;免疫抗体可干扰正常胚胎和内膜间的组织相容性,影响胚胎着床和胚胎发育;导致胚胎种植失败、自然流产、早产等不良妊娠结局。临床上应给予重视并积极治疗,以提高IVF-ET的妊娠率。 In the process of embryo cultivation, the need for proinflammatory cytokines and anti-inflammatory cytokines balance, in order to ensure the successful establishment and maintenance of pregnancy. Endometritis or subclinical endometrial infection destroys the balance between the various factors to form a cell and embryo toxic endometrial microenvironment, is not conducive to sperm survival and embryo implantation; pathogens causing inflammation can also be stimulated The body’s immune response, resulting in a large number of sensitized activated cells and a variety of cytokines, inflammatory cells, killing and phagocytosis of sperm; immune antibodies can interfere with normal embryo and endometrial tissue compatibility, affecting embryo implantation and embryo Development; leading to failed embryo implantation, spontaneous abortion, premature delivery and other adverse pregnancy outcomes. Clinic should pay attention and active treatment to improve the pregnancy rate of IVF-ET.