睾丸支持细胞(Sertoli cell)是曲细精管内唯一与生精细胞直接接触的体细胞,在生精过程中起免疫屏障、支持、营养和调节作用。相邻支持细胞、支持细胞与生精细胞之间的连接类型包括紧密连接、锚定连接和缝隙连接。这些连接结构与精子发生过程紧密联系,连接结构紊乱或异常,会干扰精子发生过程中的信号通路、生精细胞迁移、精子形态形成和精子极性维持等,引起生精功能障碍,导致男性生育力下降,甚至不育。 Sertoli cells, the only somatic cells in the seminiferous tubules that are in direct contact with spermatogenic cells, function as immunological barriers, support, nutrition and conditioning during spermatogenesis. The types of connections between adjacent supporting cells, supporting cells and spermatogenic cells include tight junctions, anchoring junctions and gap junctions. These connective structures are closely linked to the process of spermatogenesis, with disordered or abnormal connective structures that interfere with the signaling pathways during spermatogenesis, the migration of spermatogenic cells, the formation of spermatozoa and the maintenance of sperm polarity, resulting in dysfunctional spermatogenesis resulting in male fertility Force decreased, or even infertile.