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Apoptin是由鸡贫血病毒编码的一种小分子蛋白,它以非P53依赖性途径诱导不同类型人肿瘤细胞的凋亡,不受Bcl-2的抑制作用。令人感兴趣的是Apoptin不诱导人类正常细胞的凋亡,但当正常细胞被病毒转化后则易受Apoptin诱导的凋亡。这些特性使得Apoptin很可能成为一种极具潜力的抗肿瘤生物制剂。
Apoptin is a small molecule protein encoded by chicken anemia virus that induces apoptosis in different types of human tumor cells in a non-P53-dependent manner and is not inhibited by Bcl-2. Interestingly, Apoptin does not induce apoptosis in normal human cells, but normal cells are susceptible to Apoptin-induced apoptosis when transformed with virus. These features make Apoptin is likely to become a potential antitumor biological agents.