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目的对老年慢性阻塞性肺疾病加重期(AECOPD)的患者,比较使用激素治疗前后的血气及血糖结果。方法将156例老年AECOPD住院患者随机分成吸入激素组和静脉滴注激素组,比较两组治疗前后的PaO2、PaCO2、pH、空腹血糖值。结果两组治疗后与治疗前比较,PaO2均有改善;吸入激素组PaCO2改善显著且对空腹血糖无明显影响,静脉激素组空腹血糖升高。结论老年AECOPD患者中局部吸入激素疗效估于全身用药,且不良反应少。
Objective To compare the blood gas and blood glucose before and after treatment with hormone in patients with senile chronic obstructive pulmonary disease (AECOPD). Methods 156 elderly AECOPD hospitalized patients were randomly divided into inhaled hormone group and intravenous drip hormone group. PaO2, PaCO2, pH and fasting blood glucose before and after treatment were compared between two groups. Results PaO2 was improved in both groups after treatment and before treatment. PaCO2 in inhaled hormone group was significantly improved and had no significant effect on fasting blood glucose. Fasting blood glucose was increased in intravenous hormone group. Conclusion The efficacy of topical inhaled corticosteroids in elderly AECOPD patients is estimated to be systemic and with few adverse reactions.