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目的探讨老年患者呼吸道流感嗜血菌感染以及耐药性,为临床合理用药提供指导性建议。方法选取2011年11月-2013年12月呼吸科580例老年呼吸道感染患者,采集患者呼吸道分泌物标本进行流感嗜血菌的培养及鉴定,并采用K-B进行药敏试验,分析结果。结果 580例老年呼吸道感染患者痰液及咽拭子标本中,共检出流感嗜血菌47株,检出率为8.10%,对流感嗜血菌进行β-内酰胺酶检测,检出阳性14株,阳性率为29.79%;流感嗜血菌对磺胺甲噁唑/甲氧苄啶的耐药率最高,达48.94%,其次对氨苄西林、氯霉素等耐药率均较高,分别为31.22%、23.41%。结论老年患者呼吸道流感嗜血菌检出率较高,且β-内酰胺酶有较高的阳性率,对治疗影响较大,应保持对流感嗜血菌的检测,合理临床用药。
Objective To investigate the respiratory infection of Haemophilus influenzae in elderly patients and its drug resistance and to provide some guidance for the rational use of drugs. Methods From November 2011 to December 2013, 580 elderly patients with respiratory tract infection were recruited. Respiratory secretions specimens were collected for the culture and identification of Haemophilus influenzae. Susceptibility tests were performed using K-B and the results were analyzed. Results A total of 47 strains of Haemophilus influenzae were detected in sputum and throat swabs of 580 elderly patients with respiratory tract infection, the detection rate was 8.10%. The positive rate of β-lactamase in Haemophilus influenzae was 14 The positive rate was 29.79%. The susceptible rate of Haemophilus influenzae to sulfamethoxazole / trimethoprim was the highest (48.94%), followed by that of ampicillin and chloramphenicol 31.22%, 23.41%. Conclusion In elderly patients, the detection rate of Haemophilus influenzae is high, and the positive rate of β-lactamase is high, which has a great influence on the treatment. Hemophilus influenzae should be detected and rational clinical use should be made.