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为研究胚胎时期大鼠海马结构的发育状况，用浸泡固定、石蜡切片、混合尼氏染色方法，观察了Ｅ１４、Ｅ１６、Ｅ１８、Ｅ２２天大鼠胚胎海马结构的发育过程。结果：Ｅ１４天基本上能区分出海马原基。Ｅ１６天海马原基背侧与下托部神经上皮延续，腹侧与隔区神经上皮及脉络丛基质相连续；此时海马原基可区分出３部分，即背侧的阿蒙角神经上皮，其下的原始齿状回神经上皮，腹侧的伞部胶质上皮。Ｅ１８天海马裂形成，将阿蒙角神经上皮与齿状回生发基质区分开来；ＣＡ１区锥体层和海马伞开始出现，齿状回外臂和门也开始形成并第一次见向齿状回迁移的细胞。Ｅ２２天海马裂消失，阿蒙角分子层与齿状回分子层贴在一起；ＣＡ１区锥体层增厚，ＣＡ３区锥体层出现并穿透门区；阿蒙角神经上皮变成单层结构，中间层变薄，仍见大量逗留的锥体细胞，海马槽形成；齿状回外臂轮廓出现，颗粒细胞呈单层排列，内臂起始部开始形成；ＣＡ３区中间层周围及个部附近见大量的细胞正朝门区迁移。研究表明：出生前阿蒙角ＣＡ１、ＣＡ３区锥体层已经形成，齿状回外臂的轮廓已形成，内臂刚开始出现，其轮廓将于出生后形成。
To study the developmental status of hippocampal formation in rat embryos, the developmental process of hippocampal formation in E14, E16, E18 and E22 rats was observed by immersion, paraffin sections and mixed Nissei staining. Results: E14 days basically can distinguish the hippocampus primordium. E16 day hippocampal primordial dorsal and inferior part of the continuation of the neural epithelium, the ventral and parietal neuroepithelial and choroid plexus matrix phase; at this time the hippocampus can be divided into three parts of the original base, that dorsal side of the A12 nerve epithelium, Under its primitive dentate gyrus epithelium, ventral glial epithelium. E18 day hippocampal formation, the Avalon nerve epithelium and dentate gynecological germplasm distinguish; CA1 pyramidal layer and the hippocampus began to appear, the dentate gyrus outer arm and the door also began to form and first saw teeth Retrograde cells. E22 day hippocampi disappeared, Ammon angle molecular layer and dentate molecular layer attached together; CA1 pyramidal layer thickened, CA3 pyramidal layer appears and penetrate the door area; A Mongolian nerve epithelium into a single layer Structure, the middle layer thinning, still see a large number of stay of pyramidal cells, hippocampal formation; dentate gyroidal outline appears, monolayer arrangement of granular cells, the beginning of the formation of the inner arm; CA3 intermediate layer around and a See a large number of cells in the vicinity of the Ministry is moving toward the door area. Studies have shown that: before birth, the pyramidal layers of CA1 and CA3 in Ammonian horn have been formed, the outline of the dentate gyrus outer arm has been formed, the inner arm has just begun to appear, and the outline of the inner arm will be formed after birth.