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目的观察大剂量左氧氟沙星静滴治疗呼吸系统感染的安全性与有效性。方法对70例呼吸道细菌感染患者,分为高剂量左氧氟沙星(可乐必妥)500mg/d一次静脉滴注的治疗组和常规剂量300mg/次每天两次静脉滴注的对照组,疗程5~10天后进行治疗前后两组间的比较。结果治疗组和对照组的临床总有效率分别为93.3%和91.6%,经统计学处理差异无显著性;不良反应发生率治疗组和对照组分别为6.6%和6.1%,两组间无统计学意义;但三日症状缓解率差异有统计学意义,且总疗程治疗组较对照组缩短。结论高剂量左氧氟沙星治疗呼吸道感染疗效良好,副作用较小,不良反应较少,是治疗轻中重度呼吸系统感染较理想的药物。
Objective To observe the safety and effectiveness of high-dose levofloxacin intravenous infusion in the treatment of respiratory infections. Methods Seventy patients with bacterial infection of respiratory tract were divided into two groups: high dose levofloxacin 500mg / d intravenous drip treatment group and conventional dose 300mg / twice daily intravenous drip control group. The course of treatment was 5 to 10 days Before and after treatment comparison between the two groups. Results The total clinical effective rates of the treatment group and the control group were 93.3% and 91.6%, respectively, and no significant difference was found between the two groups. The incidence of adverse reactions in the treatment group and the control group were 6.6% and 6.1% respectively, with no statistical difference between the two groups However, the three-day symptom relief rate difference was statistically significant, and the total course of treatment group than the control group shortened. Conclusion High-dose levofloxacin is effective in the treatment of respiratory tract infections with less side effects and fewer side effects. It is an ideal drug for the treatment of mild to moderate respiratory infections.