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目的:比较同期住院的尿石症患者与非结石患者血生化、尿生化及尿α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)有无差异,并探讨其意义。方法:对比尿石症组66例(男45例,女21例),非结石(对照)组34例(男22例,女12例)统一生化仪器测定空腹血液生化及24 h尿生化,放免法测定α1-MG及β2-MG含量。结果:两组间年龄、性别比差异无统计学意义。尿石症组血肌酐、尿素氮水平高于对照组,差异有统计学意义。尿石症组和对照组尿电解质水平差异无统计学意义,尿石症组尿α1-MG和β2-MG的含量高于对照组,微球蛋白差异有统计学意义。尿石症多尿组尿Ca、P水平高于尿石症少尿组及对照组,差异有统计学意义。结论:尿石症患者进行一次完备的24 h代谢评估是必要的,尿α1-MG、β2-MG可能在泌尿系结石的发病中起一定作用。
OBJECTIVE: To compare the blood biochemical and urinary biochemical characteristics and urinary α1-microglobulin (α1-MG) and β2-microglobulin (β2-MG) in patients with urolithiasis and non-calcific patients hospitalized in the same period and to discuss its significance. Methods: A total of 66 urolithiasis patients (45 males and 21 females) and 34 patients (22 males and 12 females) with urolithiasis were enrolled in this study. Fasting blood biochemistry and 24 h biochemical tests were performed in patients with urolithiasis. Method for the determination of α1-MG and β2-MG content. Results: There was no significant difference in age and sex between the two groups. Urinary stone group serum creatinine, urea nitrogen levels higher than the control group, the difference was statistically significant. There was no significant difference in urinary electrolytes between urolithiasis group and control group. The contents of urinary α1-MG and β2-MG in urolithiasis group were higher than those in control group, and the difference of microglobulin was statistically significant. Urinary calculi polyuria group urinary Ca, P levels higher than urolithiasis oliguria group and control group, the difference was statistically significant. Conclusion: A complete 24-h metabolic assessment of urolithiasis is necessary. Urinary α1-MG and β2-MG may play a role in the pathogenesis of urolithiasis.