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目的:探讨反复自然流产患者感染解脲脲原体(Uu)与外周血IL-8、IL-10水平变化的关系。方法:选择98例反复自然流产患者(观察组)和正常同期匹配妊娠者98例(对照组),采用酶联免疫吸附试验对两组外周血IL-8、IL-10水平进行测定,两组分别采集宫颈分泌物进行支原体培养与鉴定。结果:反复自然流产组血IL-8水平显著高于对照组,而IL-10水平显著低于对照组,差异均有统计学意义(P<0.05);Uu感染阳性率显著高于对照组,差异有统计学意义(P<0.05)。结论:Uu感染可引起孕妇血清IL-8水平增高、IL-10水平降低;IL-8水平过高、IL-10水平过低可增加反复自然流产的风险。
Objective: To investigate the relationship between Uu infection in patients with recurrent spontaneous abortion and the levels of IL-8 and IL-10 in peripheral blood. Methods: Ninety-eight cases of recurrent spontaneous abortion (observation group) and 98 cases of matched normal pregnancy (control group) were selected. The levels of IL-8 and IL-10 in peripheral blood were measured by enzyme-linked immunosorbent assay Cervical secretions were collected for mycoplasma culture and identification. Results: The level of blood IL-8 in recurrent spontaneous abortion group was significantly higher than that in control group, but the level of IL-10 was significantly lower than that in control group (P <0.05). The positive rate of Uu infection was significantly higher than that in control group The difference was statistically significant (P <0.05). CONCLUSION: Uu infection can cause the increase of serum IL-8 level and decrease of IL-10 level in pregnant women. The high level of IL-8 and the low level of IL-10 may increase the risk of recurrent spontaneous abortion.