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目的 :探讨妊娠肝内胆汁瘀积症 (ICP)妇女表皮生长因子 (EGF)的变化及其两者之间的关系。方法 :采用双抗体夹心ABC -Elisa法测定 3 6例ICP妇女血清及胎儿脐静脉血清EGF浓度 ,并与正常妊娠妇女 3 5例进行对照分析。结果 :ICP组孕妇血清EGF浓度及胎儿脐静脉血清EGF浓度均低于对照组 ,差异有显著性 (P <0 0 5 )。ICP组胎儿脐静脉血中EGF浓度有随胎儿体重降低而下降的趋势 ,但差异无显著性。ICP组及对照组孕妇血清EGF水平与胎儿脐静脉血清EGF水平比较 ,差异无显著性 (P>0 0 5 )。结论 :ICP妇女所发生的IUGR与孕妇血清及胎儿血中EGF降低有关。
Objective: To investigate the changes of epidermal growth factor (EGF) in women with intrahepatic cholestasis of pregnancy (ICP) and their relationship. Methods: EGF concentration in serum and fetal umbilical vein of 36 women with ICP was measured by double antibody sandwich ABC-Elisa method and compared with 35 normal pregnant women. Results: The levels of serum EGF and fetal umbilical serum EGF in ICP group were lower than those in control group (P <0.05). The concentration of EGF in fetal umbilical blood of ICP group decreased with the decrease of fetal weight, but the difference was not significant. There was no significant difference in the levels of serum EGF between the pregnant women with ICP and the control group and fetal umbilical vein serum (P> 0.05). Conclusions: IUGR in ICP women is associated with decreased EGF in serum and fetal blood in pregnant women.