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目的 探讨血清同型半胱氨酸(Hcy)与卒中后抑郁的关系.方法 急性脑卒中患者85例,根据血清Hcy水平分为两组:Hcy＞15 μmol/L为A组(40例)；Hcy≤15μmol/L为B组(45例).比较两组患者卒中后抑郁的发生率、抑郁自评量表(SDS)评分、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)及血清脑源性神经营养因子(BDNF)水平.结果 A组抑郁症的发病率高于B组(50.0％ vs.28.9％)(P＜0.05);A组SDS评分高(P＜0.05);A组血清BDNF浓度较B组低[(831.7±289.0) pg/ml vs.(1276.6±277.9) pg/ml](P＜0.05).结论 高Hcy血症患者卒中后抑郁发生的比例较高,且程度严重；BDNF可能参与了高Hcy血症的病理生理作用.“,”Objective To investigate the correlation between serum homocysteine (Hcy) and post stroke depression (PSD).Methods A total of 85 patients with acute stroke was divided into group A(serum Hcy＞15μmol/L,40 cases) and group B(serum Hcy≤15μmol/L,45 cases).The incidence of PSD,scores of self-rating depression scale(SDS) and National Institutes of Health Stroke Scale(NIHSS),Barthel index (BI),serum level of brain-derived neurotrophic factor (BDNF) were compared between two groups.Results The incidence of PSD in group A was higher than that in group B(50.0％ vs.28.9％)(P＜0.05).The score of SDS in group A was higher than that in group B(P＜0.05).Serum level of BDNF in group A was lower than that in group B[(831.7±289.0) pg/ml vs.(1276.6±277.9) pg/ml] (P＜0.05).Conclusion The stroke patients with hyperhomocysteinemia has a higher incidence and more severity of PSD.BDNF may take a role in the pathophysiology of hyperhomo-cysteinemia.