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目的 :对水包油 (O/W )型甲苯咪唑乳剂的体外释药行为进行研究。方法 :采用动态透析法。结果 :甲苯咪唑的溶解度及其从油相扩散至水相的过程是药物释放的限速步骤。结论 :与片剂相比 ,乳剂和混悬剂中的甲苯咪唑的释放表现出明显的缓释作用
Objective : To study the in vitro release behavior of oil-in-water (O/W) mebendazole imidazole emulsions. Methods: Dynamic dialysis was used. RESULTS: The solubility of mebendazole and its diffusion from the oil phase to the aqueous phase were the rate-limiting steps for drug release. Conclusion: Compared with tablets, the release of mebendazole in emulsions and suspensions showed significant sustained release