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帕金森氏病(PD)随着疾病的发展,药物疗效逐渐下降,有些病例出现严重副作用,外科治疗一般认为仅对运动过多症状和耐药病人有效。苍白球腹后部切开术(PVP)可有效地解除PD的运动减少和运动过多症状。本文作者研究了PD病人采用PVP的结果,适应症及生理。 1990～1994年,作者对126例PD患者行PVP共194次。单侧58例,双侧68例,有49例一次同时完成双侧手术,另19例分期行双侧PVP,平均间隔时间为7个月(4～14月)。平均年龄62(31～80)岁,病程平均为11(2～24)年。对每一病人术前均行控制PD症状的药物治疗,术中评价症状改变情况,术后1
Parkinson’s disease (PD) With the development of the disease, the efficacy of the drug gradually decreases. In some cases, serious side effects occur. Surgical treatment is generally considered as effective only in patients with hyperactivity and drug resistance. Posterior globus pallidotomy (PVP) is effective in relieving PD motility and excessive exercise. The authors studied the outcomes, indications, and physiology of patients with PD who underwent PVP. From 1990 to 1994, the authors conducted a total of 194 PVP events in 126 PD patients. One side of 58 cases, bilateral 68 cases, 49 cases of bilateral surgery at the same time complete the other 19 cases were staged line bilateral PVP, the average interval of 7 months (4 ~ 14 months). The average age was 62 (31-80) years old, with an average duration of 11 (2-24) years. For each patient preoperative control of PD symptoms of drug treatment, intraoperative evaluation of symptoms, postoperative 1