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表皮生长因子受体（ＥＧＦＲ）是分子量为１７０ｋｕ的跨膜糖蛋白，与细胞的分裂增殖有关。本研究应用放射配基结合分析法，测定了３０例胃癌患者的癌组织及正常胃组织，结果胃癌组织的ＥＧＦＲ含量为（１０．３６±２．２１）ｆｏｍｌ／Ｌ蛋白，明显高于正常胃组织的ＥＧＦＲ含量（４．２２±１．８０）ｆｍｏｌ／ｍｇ蛋白，（Ｐ＜０．０１）。不同胃癌病理类型中，分化差的ＥＧＦＲ高于分化好的，但统计学处理无显著性差异。胃癌组织中的ＥＧＦＲ具有很高的亲和力Ｋｄ＝（２．２５±０．６８）ｎｍｏｌ。我们的结果表明ＥＧＦＲ在胃癌组织中的高表达可能在胃癌的发生、发展中起重要作用，但ＥＧＦＲ能否作为判断胃癌分化好坏及预后的指标尚难定论，有待进一步研究。
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with a molecular weight of 170ku and is involved in the proliferation of cells. In this study, radioligand binding assay was used to determine the cancer tissues and normal gastric tissues of 30 patients with gastric cancer. The result showed that the EGFR content of gastric cancer tissue was (10.36±2.21)foml/L protein, which was significantly higher than that of normal stomach. The tissue EGFR content (4.22±1.80) fmol/mg protein, (P<0.01). Among different pathological types of gastric cancer, the poorly differentiated EGFR was higher than the well-differentiated one, but there was no significant difference in statistical processing. EGFR in gastric cancer tissues has a high affinity Kd=(2.25±0.68) nmol. Our results suggest that the high expression of EGFR in gastric cancer tissues may play an important role in the occurrence and development of gastric cancer. However, whether EGFR can be used as an indicator to judge the differentiation of gastric cancer and prognosis is still difficult to determine, and needs further study.