综述了锌在小儿神经系统疾病和内分泌代谢性疾病中的作用及临床意义，尤其是对癫病的发病起重要作用．大量资料证明高锌与癫痫发作有关，其血锌值明显高于健康儿童，因此在治疗中不要轻易补锌．还综述了锌与智能发育障碍、生长发育障碍、多动症、胎儿畸形、遗传往感音神经性聋等疾病的关系及在治疗糖尿病、肝豆状核变性等内分泌和代谢性疾病时要注意维持锌的正常动态平衡． This review summarizes the role and clinical significance of zinc in children with neurological diseases and endocrine and metabolic diseases, especially plays an important role in the pathogenesis of epilepsy. A large number of data prove that high zinc and seizures related to the blood zinc value was significantly higher than healthy children, so do not easily zinc in the treatment. Also reviewed the relationship between zinc and mental retardation, growth and development disorders, ADHD, fetal malformations, genetic to sensorineural hearing loss and other diseases and in the treatment of diabetes, Wilson’s disease and other endocrine and metabolic diseases should pay attention to maintaining zinc The normal dynamic balance.