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小细胞(SC)肺癌约构成所有原发性肺癌的20～25％。与其它原发性肺癌不同的一个特点是,SC肺癌对放射治疗及化疗有高度的反应性。大多数患者对于联合化疗或联合化疗合并放疗皆有良好的临床治疗反应。但不幸的是,不少患者会发生复发,此时对进一步的化疗具有抵抗性,最终导致病人的死亡。另一方而,已知大多数的SC肺癌细胞在组织培养中仍能保持其形态以及生化的稳定性。然而也有些细胞可呈现从SC到大细胞(LC)的形态改变。为此本文旨在研
Small cell (SC) lung cancer accounts for about 20% to 25% of all primary lung cancers. One feature different from other primary lung cancers is that SC lung cancer is highly responsive to radiation therapy and chemotherapy. Most patients have good clinical response to combination chemotherapy or combination chemotherapy with radiotherapy. Unfortunately, many patients experience recurrences, which are resistant to further chemotherapy and eventually lead to patient death. On the other hand, it is known that most SC lung cancer cells maintain their morphological and biochemical stability in tissue culture. However, some cells may also exhibit morphological changes from SC to large cells (LC). The purpose of this article is to study